Phase Separation of DNA and RNA - How biomolecules organize themselves

DNA and RNA are not just carriers of genetic information – they actively shape the organization of the cell. Through phase separation, they can form distinct compartments, influencing cellular structure and function.

 

RNA Condensates in the Cell

RNA, a chain of nucleotides, plays a key role in cellular processes. It can interact with other RNA molecules and form larger structures through phase separation.

 

DNA Condensation in the Nucleus

DNA, the molecule of life, must be compactly organized in the nucleus. Beyond classic packaging with histones, DNA can also condense on its own.

 

Phase Separation as a Cellular Principle

Biomolecules like DNA and RNA can segregate into dense and dilute phases under physiological conditions. This fundamental process drives cellular self-organization.